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KMID : 0922220090090010009
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Journal of the Korean Musculoskeletal Transplantation Society
2009 Volume.9 No. 1 p.9 ~ p.20
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The role of Platelet Derived Growth Factor (PDGF) on nerve regeneration in segmental defect of rabbit sciatic nerve into Nerve Conduit
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Lee Jung-Ho
Rhee Seung-Koo
Park Jae-Cheol
Lee Sang-Myung
Lee Jung-Han
Choi Ki-Bum
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Abstract
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Purpose: To investigate the role of recombinant human PDGF on the regeneration of the 12 mm of sciatic nerve gap in 24 rabbits and the possibility of clinical use of Goretex tube as an artificial nerve conduits.
Materials & Methods: The gap was coapted with 16 mm in length and 3 mm in width of Goretex tube, filled with collagen (group I) and recombinant human PDGF, 0.25 mg/kg (group II) mixture in each 12 rabbits. All the animals were followed up for 9 weeks after surgery, and every 3 rabbits in each group at 3, 5, 7 and 9th week were examined with EMG on affected gastrocnemius muscle, followed by sacrifice the animal for histologic examinations.
Results: There was no significant differences between the two groups in the amplitude and distal latency of evoked muscle action potentials in early stage but a bit improved in later. There are apparently good effect of PDGF to enhance motor nerve regeneration.
Conclusion: The Goretex tube can be used for one of good nerve conduits, and the recombinant human PDGF in neural damage might act to increase the number of new blood vessels and to proliferate the non-neuronal cells at the early stage of experiment, and also to mature the regenerating axon at the end of experiment.
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KEYWORD
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Platelet derived growth factor, Goretex tube, Nerve gap, Nerve conduits
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